Sulfamethizolum [Inn-Latin]: Full Drug Profile
Sulfamethizolum [Inn-Latin] - General Information
A sulfathiazole antibacterial agent. [PubChem]
Pharmacology of Sulfamethizolum [Inn-Latin]
Sulfamethizolum [Inn-Latin] is a sulfonamide antibiotic. The sulfonamides are synthetic bacteriostatic antibiotics with a wide spectrum against most gram-positive and many gram-negative organisms. However, many strains of an individual species may be resistant. Sulfonamides inhibit multiplication of bacteria by acting as competitive inhibitors of p-aminobenzoic acid in the folic acid metabolism cycle. Bacterial sensitivity is the same for the various sulfonamides, and resistance to one sulfonamide indicates resistance to all. Most sulfonamides are readily absorbed orally. However, parenteral administration is difficult, since the soluble sulfonamide salts are highly alkaline and irritating to the tissues. The sulfonamides are widely distributed throughout all tissues. High levels are achieved in pleural, peritoneal, synovial, and ocular fluids. Although these drugs are no longer used to treat meningitis, CSF levels are high in meningeal infections. Their antibacterial action is inhibited by pus.
Sulfamethizolum [Inn-Latin] for patients
Take the drug with a full glass of water on an empty stomach. Increase fluid intake to 2L/day. Store in a tight, light-sensitive container at room temperature. Avoid sunlight or use sunscreen to prevent burns (avoid sunscreens containing PABA), avoid over-the-counter medications unless directed by a physician. Notify your doctor of skin rash, sore throat, fever, mouth sores, unusual bruising, and bleeding.
Sulfamethizolum [Inn-Latin] Interactions
Sulfamethizole may increase the effects of barbiturates, tolbutamide, and uricosurics. It may also interact with thiazides (increased thrombocytopenia), cyclosporine (increased nephrotoxicity), sulfonylurea agents (increased hypoglycemic response), warfarin (increased anticoagulant effect), methotrexate (decreased renal excretion of methotrexate), phenytoin (decreased hepatic clearance of phenytoin).
Sulfamethizolum [Inn-Latin] Contraindications
Treatment with Sulfamethizole is contraindicated in the following: hypersensitivity to sulfonamides and sulfonylureas, thiazide and loop diuretics, salicyclates, sunscreen with PABA, lactation, infants less than 2 months old, pregnancy at term, and porphyria.
Additional information about Sulfamethizolum [Inn-Latin]
Sulfamethizolum [Inn-Latin] Indication: For the treatment of urinary tract infection Mechanism Of Action: Sulfamethizolum [Inn-Latin] is a competitive inhibitor of bacterial para-aminobenzoic acid (PABA), a substrate of the enzyme dihydropteroate synthetase. The inhibited reaction is necessary in these organisms for the synthesis of folic acid. Drug Interactions: Not Available Food Interactions: Not Available Generic Name: Sulfamethizole Synonyms: Not Available Drug Category: Anti-Infectives Drug Type: Small Molecule; Approved Other Brand Names containing Sulfamethizole: Ayerlucil; Famet; Lucosil; Methazol; Microsul; Proklar; Renasul; Rufol; Sulfamethiazole; Salimol; Solfametizolo [Dcit]; Sulamethizole; Sulfa Gram; Sulfamethazole; Sulfamethizol; Sulfamethizole [Usan-Inn-Jan]; Sulfamethizolum [Inn-Latin]; Sulfamethylthiadiazole; Sulfametizol [Inn-Spanish]; Sulfapyelon; Sulfstat; Sulfurine; Sulphamethizole; Sulphamethyltiadiazole; Tetracid; Thidicur; Thiosulfil; Thiosulfil Forte; Ultrasul; Urocydal; Urodiaton; Urolucosil; Urosulfin; Uroz; Absorption: Rapidly absorbed. Toxicity (Overdose): Not Available Protein Binding: 98-99% Biotransformation: Hepatic. Half Life: 3-8 hours Dosage Forms of Sulfamethizolum [Inn-Latin]: Tablet Oral Chemical IUPAC Name: 4-amino-N-(5-methyl-1,3,4-thiadiazol-2-yl)benzenesulfonamide Chemical Formula: C9H10N4O2S2 Sulfamethizole on Wikipedia: https://en.wikipedia.org/wiki/Sulfamethizole Organisms Affected: Enteric bacteria and other eubacteria